NIH director urges vaccinated Americans to receive booster injections of Covid to curb breakthrough infections during the holidays

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A healthcare professional is preparing a dose of COVID-19 in the central Israeli city of Modi’in on October 19, 2021.

Gil Cohen Magen Xinhua News Agency Getty Images

Director of the National Institute of Health dr. Francis Collins advises fully vaccinated Americans to give themselves Covid restorative injections to prevent breakthroughs during the holidays, citing data from Israel showing declining effectiveness Pfizer in BioNTech’s Covid-19 vaccine against the delta variant.

A team from the Technion-Israel Institute of Technology in Haifa analyzed nearly 4.8 million fully vaccinated adults, of whom 13,426 were positive for Covid. Although Collins noted that the chances of breakthrough cases are “relatively rare,” Israeli researchers found higher rates of infection in all age groups among individuals who received a second dose in mid-January than those who completed vaccination in February and March.

“Although the Delta version has certainly played a role in the resurgence of COVID-19 in recent months, these findings suggest that weakened immunity is also an important factor,” Collins wrote in a blog post on the NIH website on Tuesday. “Understanding this dynamic is essential for making critical political decisions.”

On December 20, Israel began allowing vaccination to anyone over the age of 60. The researchers reported 3.3 confirmed infections per 1,000 people in this age group who received their last vaccination in the second half of January, the highest case rate in the study period July 11-31.

But the rate dropped among individuals aged 60 or over when they were later vaccinated. The study recorded 2.2 confirmed infections per 1,000 people aged 60 or over who were vaccinated against Covid in the second half of February, and 1.7 infections per 1,000 among those vaccinated in the second half of March.

“The link between the rate of confirmed infections and the vaccination period provides a measure of weakened immunity,” the report, released on October 27, said. “Without the weakening of immunity, we would expect not to notice differences in infection rates between people who have been vaccinated at different times.”

Although the researchers said they found similar results in different age groups, the study noted that weakened immunity in individuals aged 16 to 59 could be biased, as it was mostly medical staff and people with weakened immune systems in this age group eligible for vaccination in January and February.

Researchers again this summer did not “separate the contribution of vaccine breakthrough due to impaired immunity from the contribution due to a change in the predominant variant.” More than 98% of positive cases in Israel have originated from the delta version since June, the report said, noting that the analysis showed the impact of weakening immunity specifically against the delta.

The study added that the Israeli Ministry of Health used the findings of the study as a basis for approving recovery funds at least five months after receiving the second dose of Pfizer on July 30. Collins said Israeli data helped influence the CDC’s decision to recommend amplifiers from Pfizer, Modern in Johnson & Johnson also this fall.

Amplifiers are available in the US for Pfizer and Moderna recipients aged 65 and over, adults with conditions that could cause Covid complications, anyone aged 18 or over living or working in shared environments, and front-line employees who may be exposed to the virus . All adult J&J recipients are eligible for rehabilitation therapy, regardless of their health or occupational risk factors.

Israel has started giving boosters to people over 60 years of age July, but Prime Minister Naftali Bennett announced on August 29 that anyone aged 12 and over could get a third injection.

Pfizer CEO Albert Bourla said in July that the effectiveness of the Covid social vaccine dropped to about 84% within four to six months of receiving the second dose. But Israeli data published that month showed that the Pfizer vaccine was only 16% effective in preventing symptomatic diseases in recipients who underwent a series of vaccinations in January.

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