Wales came last in Group 4 of the A-League and will be eliminated if Poland, who are three points above them, improve on their result against the Netherlands.
Wales face Poland in their final group game in Cardiff on Sunday, but their fate could already be sealed if they lose to Belgium and the Poles pick up a point.
Time is also running out before the World Cup in November, as this game against Belgium will be their penultimate before the opening match against the USA in Qatar.
Here’s everything you need to know ahead of the game.
When is Belgium vs Wales?
The match will kick off on Thursday 22nd September at 19:45 BST.
How can I watch it?
It will be shown live on Premier League Sports 1 and S4C in Wales. You can also watch it live on Premier Sports player.
Belgium: Courtois; Debast, Alderweireld, Vertonghen; Meunier, Tielemans, Witsel, Carrasco; De Bruyne, Batshuayi, Hazard
Wales: Hennessey; Mepham, Rodon, Norrington-Davies; Roberts, Ampadu, Smith, N Williams; Johnson, Moore, James