Louise Fletcher of One Flew Over The Cuckoo’s Nest has died aged 88.

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Oscar winner Louise Fletcher, famous for playing Nurse Ratched in One Flew Over the Cuckoo’s Nest, has died at the age of 88 at her home in France.

Oscar winner Louise Fletcher has died at the age of 88.

The actress’ family confirmed that she died peacefully at her home in Montdurausso, France to Deadline but did not disclose the cause of death.

She famously played Nurse Ratched in Miloš Forman’s One Flew Over the Cuckoo’s Nest (1975), co-starring Jack Nicholson, considered by many to be one of the best movies ever made.

The role of Nurse Ratched won her the Academy Award for Best Actress at the 48th Academy Awards in Los Angeles in March 1976, as well as Golden Globe and BAFTA Award.

RIP: Oscar winner Louise Fletcher has died at the age of 88 at her home in Montdurausse, France, Deadline reports; the actress is seen in January 2012

Fletcher is the second of four children born to the Reverend Robert Capers Fletcher and his wife Estelle, who were both deaf and worked with the deaf and hard of hearing.

Born in Birmingham, Alabama, spoken by an aunt who could hear, he showed an interest in the art of acting as a youth.

Eventually she did her professional debut in 1958 when she scored four different television guest roles on Flight, Playhouse 90, Bat Masterson and Yancy Derringer.

Fletcher made her film debut in 1963 in A Gathering of Eagles, starring Rock Hudson, Rod Taylor, Mary Peach and Barry Sullivan.

Iconic: Fletcher famously played Nurse Ratched in One Flew Over the Cuckoo's Nest (1975), directed by Milos Forman and starring Jack Nicholson.

Iconic: Fletcher famously played Nurse Ratched in One Flew Over the Cuckoo’s Nest (1975), directed by Milos Forman and starring Jack Nicholson.

Bonafide hit: The psychological comedy-drama was a critical and box office hit, winning the Academy Awards the following year and winning Best Picture, Best Director, Best Actor, Best Actress and Best Screenplay out of nine nominations.

Bonafide hit: The psychological comedy-drama was a critical and box office hit, winning the Academy Awards the following year and winning Best Picture, Best Director, Best Actor, Best Actress and Best Screenplay out of nine nominations.

It was 11 years before she landed her next film role, which came in the crime drama Thieves Like Us, starring Keith Carradine, Shelley Duvall, John Schuck, Bert Remsen and Tom Skerritt.

Her performance in Robert Altman’s Thieves Like Us helped her gain the attention of Miloš Forman, and she eventually landed the role of Nurse Ratched in One Who Flew Over The Cuckoo’s Nest.

The psychological comedy-drama was a critical and box office hit and won this year’s Academy Awards by winning Best Picture, Best Director, Best Actor, Best Actress and Best Screenplay out of nine nominations.

Monumental: Fletcher, who grew up with deaf parents, famously accepted her Best Actress Oscar for One Who Flew Over The Cuckoo's Nest using sign language

Monumental: Fletcher, who grew up with deaf parents, famously accepted her Best Actress Oscar for One Who Flew Over The Cuckoo’s Nest using sign language

Fletcher used sign language during her acceptance speech for the Best Actress award, which still stands as one of the most memorable moments in Academy Awards history.

Throughout the years, she has worked consistently in both film and television. In fact, she is best known to many fans for her recurring role as Bajoran religious leader Kai Winn Adami in the hit series Star Trek: The Deep Nine (1993-1999).

Fletcher was married to film producer Jerry Bick from 1959 until their divorce in 1977. She is survived by sons John and Andrew Bick; granddaughter, Emilee Kaya Bick; sister Roberta Ray and brother-in-law Edward Ray; and 10 nieces and nephews, according to Rok.

Another breakthrough: Fletcher is also known to many fans for her recurring role as Bajoran religious leader Kai Winn Adami on the hit Star Trek: Nine Deep Spaces (1993-1999).

Another breakthrough: Fletcher is also known to many fans for her recurring role as Bajoran religious leader Kai Winn Adami on the hit Star Trek: Nine Deep Spaces (1993-1999).

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